Potassium Hydroxide → HCID 54019477, compound

HRID 268088Notes

Reaction equation

HRID 268088 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:19][C:18]([C:20]#[N:21])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:23][OH:24].[OH-].[K+]>C(O)C>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:19][C:18]([C:20](=[N:23][OH:24])[NH2:21])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 21553305HCID 21553305, compound

Product 1

HCID 54019477HCID 54019477, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 30 g (0.11 mole) of 5-(p-benzyloxyphenyl)-2-furonitrile, 8.3 g (0.12 mole) of hydroxylamine hydrochloride, 8 g (0.12 mole) of KOH and 330 ml of absolute ethanol was refluxed for 11/2 hours, cooled in an ice bath and filtered. The solid obtained was recrystallized from 95% ethanol to yield 19 g (56%). An analytical sample was obtained by drying a sample in the vacuum pistol at the temperature of refluxing CHCl3, m.p. 145°-146°.

Workup

  1. temperaturewas refluxed for 11/2 hours
  2. temperaturecooled in an ice bath
  3. filtrationfiltered
  4. customThe solid obtained
  5. customwas recrystallized from 95% ethanol
  6. customto yield 19 g (56%)
  7. customAn analytical sample was obtained
  8. dry with materialby drying a sample in the vacuum pistol at the temperature of refluxing CHCl3, m.p. 145°-146°

Sources & evidence

ORD record
ord-d864fe92228c40499324f4d28fb62a2f
Source dataset
uspto-grants-1976_03
Patent number
US03946049

Reaction notes

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