Borane → HCID 68146681, compound

HRID 268173Notes

Reaction equation

HRID 268173 reaction equation
[CH3:1][N:2]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:15])[F:14])=[CH:12][C:7]=2[C:6](=O)[N:5]2[CH2:18][CH2:19][CH2:20][CH:4]2[C:3]1=[O:21].B>O1CCCC1>[CH3:1][N:2]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:14])[F:15])=[CH:12][C:7]=2[CH2:6][N:5]2[CH2:18][CH2:19][CH2:20][CH:4]2[C:3]1=[O:21]

Participants

4

Reactant 2

HCID 6331BoraneHCID 68145803HCID 68145803, compound

Product 1

HCID 68146681HCID 68146681, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

If 1,2,3,11a-tetrahydro-10-methyl-7 -trifluoromethyl-5 H-pyrrolo[2,1-c] [1,4] benzodiazepin-5,11(10H)-dione (prepared from proline and 5-trifluoromethyl N-methylisatoic anhydride as described in Example 1) is treated with 1M borane in tetrahydrofuran as described in Example 1, the above compound is obtained.

Workup

  1. customthe above compound is obtained

Sources & evidence

ORD record
ord-ffe2def51f494cd1824b3615fa0ad198
Source dataset
uspto-grants-1976_03
Patent number
US03947408

Reaction notes

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