Potassium Carbonate → HCID 58598935, compound

HRID 268560Notes

Reaction equation

HRID 268560 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([CH3:8])[CH:7]=1.CN1CCCC1=[O:18].[NH2:19][CH2:20][CH2:21][O:22][CH:23](O)[CH3:24].C([O-])([O-])=O.[K+].[K+]>O>[N+:9]([C:5]1[CH:4]=[CH:3][C:2]([NH:19][CH2:20][CH2:21][O:22][CH2:23][CH2:24][OH:18])=[CH:7][C:6]=1[CH3:8])([O-:11])=[O:10]

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 949565-Fluoro-2-nitrotolueneHCID 21989213HCID 21989213, compound

Product 1

HCID 58598935HCID 58598935, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

2 g of 5-fluoro-2-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.63 g of 2-aminoethoxyethanol and 2.14 g of K2CO3. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 1.9 g of 2-[2-(4-nitro-3-methylphenylamino)ethoxy]ethanol (15) were obtained after purification on a column of silica.

Workup

  1. temperatureafter cooling to room temperature
  2. customThe yellow precipitate formed
  3. filtrationwas filtered off
  4. dry with materialdried over P2O5

Sources & evidence

ORD record
ord-fcff0eea1cf548e1b44f624dcd0f6835
Source dataset
uspto-grants-2008_11
Patent number
US07445645B2

Reaction notes

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