反应详情

温度

80 °C

A solution of toluene-4-sulfonic acid but-3-ynyl ester (45.0 g) and piperidine (40 mL) in ethanol (70 mL) was treated with a solution of potassium carbonate (27.8 g) in water (70 mL). The mixture was heated to 80° C. for 2 h, cooled to RT, and extracted with DCM (3×100 mL). The combined organic phases were dried (magnesium sulfate), and evaporated. Distillation of the residue (110° C., 30 mm Hg) gave the title compound as a colorless oil (17.3 g).

1. temperaturecooled to RT
2. extractionextracted with DCM (3×100 mL)
3. dry with materialThe combined organic phases were dried (magnesium sulfate)
4. customevaporated
5. distillationDistillation of the residue (110° C., 30 mm Hg)