反应详情

温度

105 °C

A stirred mixture of ethyl 4-(3-chloropropoxy)benzoate (70.0 g), piperidine (43.35 ml), sodium carbonate (45.36 g) and potassium iodide (2.37 g) in 1-butanol (650 ml) was heated at 105° C. for 16 h. The reaction was cooled to rt, diluted with EtOAc (1600 ml), washed with water (3×700 ml), saturated brine (700 ml), dried (MgSO4) and evaporated to give the title compound (D1) (82.57 g) which displayed MS and 1H NMR spectra that were identical to those of the product obtained by D1 (Method A).

1. temperatureThe reaction was cooled to rt
2. washwashed with water (3×700 ml), saturated brine (700 ml)
3. dry with materialdried (MgSO4)
4. customevaporated