Hydrochloric Acid → HCID 86612752, compound

HRID 268748Notes

Reaction equation

HRID 268748 reaction equation
[NH:1]1[C:9]2[C:4](=[C:5]([CH:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:11][CH2:12][NH2:13])[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[ClH:20]>CCOC(C)=O>[ClH:20].[NH:1]1[C:9]2[C:4](=[C:5]([CH:10]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:11][CH2:12][NH2:13])[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25261580HCID 25261580, compound

Product 1

HCID 86612752HCID 86612752, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a stirring solution of the amine (III) (0.14 g, 0.56 mmol) in EtOAc (5 ml) was added a solution of HCl (2 M in Et2O, 0.28 ml). The mixture was concentrated in vacuo affording the hydrochloride salt (IV) as a brown solid (0.16 g, quantitative yield).

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-27bcc36b03034ec1b692de3368b67f93
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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