(4-Methoxyphenyl)boronic acid → 3-(1H-Indol-6-yl)-3-(4-methoxy-phenyl)-propionic acid methyl ester

HRID 268774Notes

Reaction equation

HRID 268774 reaction equation
B(O)(O)[C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1.[CH3:12][O:13][C:14](=[O:34])[CH2:15][CH:16]([C:25]1[CH:33]=[C:32]2[C:28]([CH:29]=[CH:30][NH:31]2)=[CH:27][CH:26]=1)C1C=CC=C(OC)C=1>>[CH3:12][O:13][C:14](=[O:34])[CH2:15][CH:16]([C:25]1[CH:33]=[C:32]2[C:28]([CH:29]=[CH:30][NH:31]2)=[CH:27][CH:26]=1)[C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 59831848HCID 59831848, compound

Product 1

HCID 598316113-(1H-Indol-6-yl)-3-(4-methoxy-phenyl)-propionic acid methyl esterYield 66%

Procedure

3-(1H-Indol-6-yl)-3-(4-methoxy-phenyl)-propionic acid methyl ester XXXIV (0.51 g, 66% yield) was prepared from 4-methoxy boronic acid using the procedure described for preparation of 3-(1H-indol-6-yl)-3-(3-methoxy-phenyl)-propionic acid methyl ester XXXI (see Example 7).

Sources & evidence

ORD record
ord-cb4a7514948740aa86727a264170c5a2
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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