1,3-Propanediamine → HCID 178511125, compound

HRID 26891Notes

Reaction equation

HRID 26891 reaction equation
Cl[C:2]1[N:6]=[CH:5][NH:4][N:3]=1.[NH2:7][CH2:8][CH2:9][CH2:10][NH2:11].[O-]CC.[Na+]>C(O)C>[NH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:2]1[N:6]=[CH:5][NH:4][N:3]=1

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 2723922Sodium ethoxideHCID 178478410HCID 178478410, compound

Product 1

HCID 178511125HCID 178511125, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-chloro-1,2,4-triazole (10.3 g., 0.1 m.) and 1,3-diaminopropane (7.4 g., 0.1 m.) in ethanol containing sodium ethoxide is allowed to stand overnight. The solvent is removed to give 3-(3-aminopropylamino)-1,2,4-triazole. This intermediate is reacted with methyl isothiocyanate to give N-methyl-N'-[3-(3-(1,2,4-triazolyl)amino)propyl]thiourea.

Workup

  1. customThe solvent is removed

Sources & evidence

ORD record
ord-c7da510a76ce41419b78f6b5d93eb099
Source dataset
uspto-grants-1979_04
Patent number
US04151288

Reaction notes

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