2-Amino-2-methyl-1-propanol → 3-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide

HRID 268931Notes

Reaction equation

HRID 268931 reaction equation
[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[Br:7][C:8]1[CH:9]=[C:10]([S:14](Cl)(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=1>>[Br:7][C:8]1[CH:9]=[C:10]([S:14]([NH:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4])(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 17943m-Bromobenzenesulphonyl chloride

Product 1

HCID 435019003-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamideYield 89%

Procedure

Prepared by general procedure III from 2-amino-2-methyl-1-propanol (8.91 g, 100 mmol) and commercially available 3-bromobenzenesulfonyl chloride (2.88 mL, 20 mmol) to give the title compound as a white solid (5.47 g, 89%). MS (ISN) 306.1 [(M−H)−], 308.2 [(M+2−H)−]. mp 138° C.

Sources & evidence

ORD record
ord-15960db67a934c89948ef5d564e0109c
Source dataset
uspto-grants-2008_11
Patent number
US07446113B2

Reaction notes

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