反应详情

温度

82.5 °C

50 g (0.284 mole) of Tetrahydrothienopyridine hydrochloride (A) was reacted with 83 g (0.315 mole) of α-bromo-2-chlorophenyl acetic acid methyl ester (B) in 2.5 Lt. DMF in presence of 83 g. (0.6 mole) potassium carbonate. The reaction mixture was heated at 80-85°C under nitrogen atmosphere for 4 Hrs. The reaction mixture was filtered at RT and washed the residue with DMF. The DMF was concentrated under vacuum to obtain a viscous liquid. To this viscous liquid, water was added and the base was extracted from the aqueous layer using methylene dichloride. The methylene dichloride was concentrated under vacuum to get pure Clopidogrel base. Yield =92%

1. filtrationThe reaction mixture was filtered at RT
2. washwashed the residue with DMF
3. concentrationThe DMF was concentrated under vacuum
4. customto obtain a viscous liquid
5. extractionthe base was extracted from the aqueous layer
6. concentrationThe methylene dichloride was concentrated under vacuum