Potassium Carbonate → HCID 178478222, Verbindung

HRID 269541Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 269541
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2[NH:18][N:17]=[N:16][N:15]=2)[CH:9]=1.[CH2:19]([O:26][C:27]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=1B(O)O)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(=O)([O-])[O-].[K+].[K+].C1(C)C=CC=CC=1.C(O)C>ClCCl.O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH2:19]([O:26][C:27]1[CH:28]=[CH:29][C:30]([Cl:33])=[CH:31][C:32]=1[C:2]1[C:3]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]3[NH:18][N:17]=[N:16][N:15]=3)[CH:9]=2)=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Komponenten

8

Edukt 4

HCID 11430Potassium CarbonateHCID 41987402-Benzyloxy-5-chlorobenzeneboronic acidHCID 21863594Toluene ethanolHCID 178419370HCID 178419370, Verbindung

Produkt 1

HCID 178478222HCID 178478222, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 5-(2′-bromo-biphenyl-3-yl)-1H-tetrazole (163 mg, 0.54 mmol), 2-benzyloxy-5-chlorobenzeneboronic acid (156 mg, 0.59 mmol), potassium carbonate (589 mg, 4.33 mmol), and tetrakis(triphenylphosphine)palladium(0) (63 mg, 0.05 mmol) in 1.1 toluene/ethanol (5 ml) was stirred and heated under nitrogen for 16 hours. After cooling the mixture was diluted with dichloromethane and water. The organic phase was dried and evaporated.

Aufarbeitung

  1. temperatureheated under nitrogen for 16 hours
  2. temperatureAfter cooling the mixture
  3. customThe organic phase was dried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-e093f7ef662441fb9de78c88b9438a19
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07446222B2

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