Hydrochloric Acid → HCID 9977975, compound

HRID 269547Notes

Reaction equation

HRID 269547 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([C:12]2[C:13]([C:18]3[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=3[O:25][CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:9]=[CH:10][CH:11]=1)=[O:5])C.[OH-].[Na+].Cl>C(O)C.O>[Cl:24][C:22]1[CH:21]=[CH:20][C:19]([O:25][CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])=[C:18]([C:13]2[C:12]([C:8]3[CH:9]=[CH:10][CH:11]=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=3)=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:23]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58731009HCID 58731009, compound

Product 1

HCID 9977975HCID 9977975, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

5-Chloro-2-(3-methyl-butoxy)-[1,1′;2′,1″]terphenyl-3″-carboxylic acid ethyl ester (45 mg, 0.106 mmol) and NaOH (excess) were heated at 60° C. in ethanol (3 ml) for 2 hrs. The mixture was then cooled to room temperature, diluted with water, acidified with HCl (1M solution) and extracted with ethyl acetate. The combined extracts were dried (MgSO4) and evaporated to yield the title compound (41 mg, 98%) as a white solid.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe combined extracts were dried (MgSO4)
  3. customevaporated

Sources & evidence

ORD record
ord-4c49a511cfeb443a847fe8943d1b9e5a
Source dataset
uspto-grants-2008_11
Patent number
US07446222B2

Reaction notes

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