反应详情

A solution of 4-hydroxybenzotrifluoride (8.55 g, 52.78 mmol) in acetone (200 ml) was treated with benzyl bromide (9.87 g, 6.86 ml, 58.05 mmol) and potassium carbonate (10.94 g, 79.16 mmol). The mixture was stirred and heated to reflux under nitrogen for 3 h. After cooling, diethyl ether (400 ml) and water (400 ml) were added and the aqueous phase re-extracted with diethyl ether (100 ml). The combined organic layers were washed with water, dried (MgSO4) and the solvent removed in vacuo to leave the title compound as a white solid. (12.71 g, 95%)

1. temperatureheated
2. temperatureto reflux under nitrogen for 3 h
3. temperatureAfter cooling
4. extractionthe aqueous phase re-extracted with diethyl ether (100 ml)
5. washThe combined organic layers were washed with water
6. dry with materialdried (MgSO4)
7. customthe solvent removed in vacuo