tert-Butanol → 1,1-Dimethylethyl 3-bromo-5-iodobenzoate

HRID 269556노트

반응식

HRID 269556 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([OH:7])=[O:6].Cl.CN(C)CCCC(N=C=N)C.[C:24](O)([CH3:27])([CH3:26])[CH3:25]>CN(C)C1C=CN=CC=1.ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([O:7][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:6]

참가 물질

6

반응물 3

HCID 6386tert-ButanolHCID 51825203-Bromo-5-iodobenzoic acidHCID 219829211-(3-Dimethylaminopropyl)ethylcarbodiimide hydrochloride

생성물 1

HCID 574859731,1-Dimethylethyl 3-bromo-5-iodobenzoate

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of 3-bromo-5-iodobenzoic acid (50 g, 153 mmol), 1-(3-dimethylaminopropyl)-ethylcarbodiimide hydrochloride (30.8 g, 153 mmol), 4-dimethylaminopyridine (18.6 g, 153 mmol) and t-butanol (69.4 g, 90 ml, 153 mmol) in dichloromethane (500 ml) was stirred at room temperature overnight. The reaction mixture was washed with 2MHCl and saturated NaHCO3. The organic phase was dried and evaporated to give the title compound as a light brown solid. (48 g; 85%).

후처리

  1. washThe reaction mixture was washed with 2MHCl and saturated NaHCO3
  2. customThe organic phase was dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-9d41c9fb650b4654bde723322a0a2f97
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446222B2

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