反应详情

A mixture of 2-bromo-5-chlorophenol (3.93 g, 18.94 mmol), benzyl bromide (3.42 g, 20 mmol) and potassium carbonate (10 g, 72.46 mmol) in acetone (80 ml) was stirred and refluxed for 3 hours then cooled, evaporated and dissolved in ether/water. The organic phase was dried (magnesium sulphate) evaporated and purified by chromatography on silica eluting with ethyl acetate/iso-hexane (1:99) to give 5.51 g of white solid.

1. temperaturerefluxed for 3 hours
2. temperaturethen cooled
3. customevaporated
4. dissolutiondissolved in ether/water
5. dry with materialThe organic phase was dried (magnesium sulphate)
6. customevaporated
7. custompurified by chromatography on silica eluting with ethyl acetate/iso-hexane (1:99)