1,2-Dichloroethane → HCID 69218546, compound

HRID 269606Notes

Reaction equation

HRID 269606 reaction equation
[CH2:1]([O:8][C:9]1[CH:29]=[CH:28][C:27]([I:30])=[CH:26][C:10]=1[CH2:11][C@@H:12]([C:23]([OH:25])=[O:24])[N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:14][CH3:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:31](O)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.C(Cl)CCl>CN(C1C=CN=CC=1)C.C(#N)C>[CH2:1]([O:8][C:9]1[CH:29]=[CH:28][C:27]([I:30])=[CH:26][C:10]=1[CH2:11][C@@H:12]([C:23]([O:25][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:24])[N:13]([C:16]([O:18][C:19]([CH3:21])([CH3:20])[CH3:22])=[O:17])[CH2:14][CH3:15])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 111,2-DichloroethaneHCID 244Benzyl AlcoholHCID 66879465HCID 66879465, compound

Product 1

HCID 69218546HCID 69218546, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6342AcetonitrileSolvent

Procedure

Preparation takes place in analogy to Example 7A from 420 mg (0.68 mmol) of the compound from Example 70A, 9.77 mg (0.08 mmol) of DMAP, 173 mg (1.6 mmol) of benzyl alcohol and 184 mg (0.96 mmol) of EDC in 8 ml of acetonitrile.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-58d8a405c935436cbdea878d36d86934
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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