Sodium Azide → HCID 57440193, compound

HRID 269618Notes

Reaction equation

HRID 269618 reaction equation
CS(O[CH2:6][C@@H:7]([NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:8][CH2:9][NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])(=O)=O.[N-:26]=[N+:27]=[N-:28].[Na+]>CN(C)C=O>[C:14]([O:13][C:11](=[O:12])[NH:10][CH2:9][CH2:8][C@H:7]([NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:6][N:26]=[N+:27]=[N-:28])([CH3:17])([CH3:16])[CH3:15]

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 86601681(2S)-2,4-Bis[(tert-butoxycarbonyl)amino]butyl methanesulphonate

Product 1

HCID 57440193HCID 57440193, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Preparation takes place in analogy to Example 85A from 200 mg (0.52 mmol) of (2S)-2,4-bis[(tert-butoxycarbonyl)amino]butyl methanesulfonate (Example 90A) in 15 ml of dimethylformamide with 34 mg (0.52 mmol) of sodium azide. The product is reacted without further purification.

Workup

  1. customPreparation
  2. customThe product is reacted without further purification

Sources & evidence

ORD record
ord-ed6e1752664143da84ba51e770eab8e0
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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