Hydrochloric Acid → HCID 178479349, compound

HRID 269629Notes

Reaction equation

HRID 269629 reaction equation
[CH2:1]([O:8][C:9](=[O:42])[NH:10][CH2:11][CH2:12][NH:13][C:14](=[O:41])[C@H:15]([CH2:24][CH2:25][CH2:26][NH:27][C:28]([NH:30][C:31]([O:33]CC1C=CC=CC=1)=[O:32])=[NH:29])[NH:16]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:43]>O1CCOCC1>[ClH:43].[CH2:1]([N:30]([C:28](=[NH:29])[NH:27][CH2:26][CH2:25][CH2:24][C@H:15]([NH2:16])[C:14](=[O:41])[NH:13][CH2:12][CH2:11][NH:10][C:9](=[O:42])[O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:31](=[O:32])[OH:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178454188HCID 178454188, compound

Product 1

HCID 178479349HCID 178479349, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 334 mg (0.417 mmol) of benzyl (2-{[N5-[{[(benzyloxy)carbonyl]amino}(imino)methyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}ethyl)carbamate (Example 102A) and 17 ml of a 4M solution of hydrogen chloride in dioxane is stirred at RT for 4 h. The reaction solution is concentrated, coevaporated with dichloromethane several times, and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-3ff67b89f62c45d486058ea0410e3575
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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