Hydrochloric Acid → HCID 69218480, compound

HRID 269636Notes

Reaction equation

HRID 269636 reaction equation
C([O:8][C:9](=[O:38])[NH:10][CH2:11][CH2:12][NH:13][C:14](=[O:37])[C@@H:15]([NH:29]C(OC(C)(C)C)=O)[CH2:16][CH2:17][NH:18][C:19]([O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:20])C1C=CC=CC=1.[ClH:39]>O1CCOCC1>[ClH:39].[CH2:22]([N:10]([CH2:11][CH2:12][NH:13][C:14](=[O:37])[C@@H:15]([NH2:29])[CH2:16][CH2:17][NH:18][C:19]([O:21][CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:20])[C:9](=[O:38])[OH:8])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131727154HCID 131727154, compound

Product 1

HCID 69218480HCID 69218480, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 270 mg (0.511 mmol) of benzyl-[2-({(2S)-4-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]butanoyl}amino)ethyl]carbamate (Example 110A) and 9 ml of a 4M solution of hydrogen chloride in dioxane is stirred at RT for 2 h. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-8c1c5231d87a47e697bd2d8ad042314d
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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