Hydrochloric Acid → HCID 69217912, compound

HRID 269637Notes

Reaction equation

HRID 269637 reaction equation
[ClH:1].[CH2:2]([O:9][C:10](=[O:57])[NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:56])[C@@H:16]([NH:30][C:31](=[O:55])[C@H:32]([CH2:41][CH2:42][CH2:43][NH:44][C:45]([O:47]CC1C=CC=CC=1)=[O:46])[NH:33]C(OC(C)(C)C)=O)[CH2:17][CH2:18][NH:19][C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21])C1C=CC=CC=1.O1[CH2:63][CH2:62]OCC1>>[ClH:1].[CH2:23]([N:44]([CH2:43][CH2:42][CH2:41][C@H:32]([NH2:33])[C:31](=[O:55])[NH:30][C@@H:16]([CH2:17][CH2:18][NH:19][C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21])[C:15](=[O:56])[NH:14][CH2:13][CH2:12][NH:11][C:10](=[O:57])[O:9][CH2:2][C:63]1[CH:62]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:45](=[O:46])[OH:47])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-Dioxane2×HCID 131727155HCID 131727155, compound

Product 1

HCID 69217912HCID 69217912, compound

Procedure

3.7 ml of a 4M solution of hydrogen chloride in dioxane are added to a solution of 71 mg (0.091 mmol) of benzyl{2-[((2S)-4-{[(benzyloxy)carbonyl]amino}-2-{[N5-[(benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}butanoyl)amino]ethyl}carbamate (Example 112A) in 1.5 ml of dioxane at RT. After 4 h at RT, the reaction solution is concentrated in vacuo, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-7b992cdf4c68460e9183723e1270ec58
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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