Hydrochloric Acid → N5-[(Benzyloxy)carbonyl]-L-ornithyl-N5-[(benzyloxy)carbonyl]-N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-L-ornithinamide hydrochloride

HRID 269645Notes

Reaction equation

HRID 269645 reaction equation
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][CH2:14][C@@H:15]([C:24]([NH:26][C@H:27]([C:42]([NH:44][CH2:45][CH2:46][NH:47][C:48]([O:50][CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:49])=[O:43])[CH2:28][CH2:29][CH2:30][NH:31][C:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33])=[O:25])[NH:16]C(OC(C)(C)C)=O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:58]>O1CCOCC1>[ClH:58].[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][CH2:14][C@@H:15]([C:24]([NH:26][C@H:27]([C:42]([NH:44][CH2:45][CH2:46][NH:47][C:48]([O:50][CH2:51][C:52]1[CH:53]=[CH:54][CH:55]=[CH:56][CH:57]=1)=[O:49])=[O:43])[CH2:28][CH2:29][CH2:30][NH:31][C:32]([O:34][CH2:35][C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)=[O:33])=[O:25])[NH2:16])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86619431N5-[(Benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithyl-N5-[(benzyloxy)carbonyl]-N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-L-ornithinamide

Product 1

HCID 86619432N5-[(Benzyloxy)carbonyl]-L-ornithyl-N5-[(benzyloxy)carbonyl]-N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-L-ornithinamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation takes place in analogy to Example 122A from 70 mg (0.09 mmol) of N5-[(benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithyl-N5-[(benzyloxy)carbonyl]-N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-L-ornithinamide (Example 123A) in 0.68 ml of a 4M solution of hydrogen chloride in dioxane.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-3e5372c8bd6c4e9b84fa1b9beaaf0e0a
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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