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HRID269648

反应详情

EQUATION

反应方程式

HRID 269648 的结构方程式

REACTANTS

反应物

4
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：O=C(N[C@@H](COCc1ccccc1)C(=O)O)OCc1ccccc1
HCID6993425

N-[(Phenylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine

C18H19NO5

结构：CC(C)(C)OC(=O)NCCC[C@@H](CN)NC(=O)OC(C)(C)C
HCID57440197

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NCCC[C@@H](CNC(=O)[C@H](COCc1ccccc1)NC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C
HCID86624498

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Preparation takes place in analogy to Example 79A from 150 mg (0.46 mmol) of O-benzyl-N-[(benzyloxy)carbonyl]-L-serine and 188 mg (0.59 mmol) of tert-butyl{(4S)-5-amino-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate (Example 86A) in 6 ml of dimethylformamide with the addition of 114 mg (0.57 mmol) of EDC and 18 mg (0.13 mmol) of HOBt. The product is purified by preparative RP-HPLC (mobile phase water/acetonitrile gradient: 90:10→5:95).

WORKUP

后处理

  1. customPreparation
  2. customThe product is purified by preparative RP-HPLC (mobile phase water/acetonitrile gradient: 90:10→5:95)