Hydrochloric Acid → HCID 50939316, compound

HRID 269700Notes

Reaction equation

HRID 269700 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][C@@H:11]1[NH:29][C:28](=[O:30])[C@@H:27]([NH:31]C(OC(C)(C)C)=O)[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][C@H:46]([C:51]([NH:53][C@H:54]([C:58]([NH:60][CH2:61][CH2:62][NH2:63])=[O:59])[CH2:55][CH2:56][NH2:57])=[O:52])[CH2:47][CH2:48][CH2:49][NH2:50])=[O:44])[NH:13][C:12]1=[O:64])(C)(C)C.[ClH:66]>O1CCOCC1>[ClH:66].[ClH:66].[ClH:66].[ClH:66].[ClH:66].[NH2:31][C@H:27]1[CH2:26][C:25]2[CH:39]=[C:21]([CH:22]=[CH:23][C:24]=2[OH:40])[C:20]2=[CH:41][C:16](=[C:17]([OH:42])[CH:18]=[CH:19]2)[CH2:15][C@@H:14]([C:43]([NH:45][C@H:46]([C:51]([NH:53][C@H:54]([C:58]([NH:60][CH2:61][CH2:62][NH2:63])=[O:59])[CH2:55][CH2:56][NH2:57])=[O:52])[CH2:47][CH2:48][CH2:49][NH2:50])=[O:44])[NH:13][C:12](=[O:64])[C@H:11]([CH2:10][CH2:9][CH2:8][NH2:7])[NH:29][C:28]1=[O:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 88986937HCID 88986937, compound

Product 1

HCID 50939316HCID 50939316, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

7 mg (0.008 mmol) of tert-butyl{3-[(8S,11S,14S)-8-{[((1S)-4-amino-1-{[((1S)-3-amino-1-{[(2-aminoethyl)amino]carbonyl}propyl)amino]carbonyl}butyl)amino]carbonyl}-14-[(tert-butoxycarbonyl)amino]-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-11-yl]propyl}carbamate tris(hydroacetate) (Example 208A) are added into 0.6 ml of a 4N solution of hydrogen chloride in dioxane and stirred at RT for 30 min. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum.

Workup

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-57055587437140679404a4a4eca4930f
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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