Hydrochloric Acid → HCID 66879422, compound

HRID 269705Notes

Reaction equation

HRID 269705 reaction equation
[ClH:1].C(OC(=O)[NH:8][CH2:9][CH2:10][CH2:11][C@@H:12]1[NH:30][C:29](=[O:31])[C@@H:28]([NH:32]C(OC(C)(C)C)=O)[CH2:27][C:26]2[CH:40]=[C:22]([CH:23]=[CH:24][C:25]=2[OH:41])[C:21]2=[CH:42][C:17](=[C:18]([OH:43])[CH:19]=[CH:20]2)[CH2:16][C@@H:15]([C:44](=[O:83])[NH:45][CH2:46][CH2:47][CH2:48][C@H:49]([NH:75]C(OC(C)(C)C)=O)[CH2:50][C:51](=[O:74])[NH:52][CH2:53][C@@H:54]([NH:66]C(OC(C)(C)C)=O)[CH2:55][CH2:56][CH2:57][NH:58]C(=O)OC(C)(C)C)[NH:14][C:13]1=[O:84])(C)(C)C>O1CCOCC1>[ClH:1].[ClH:1].[ClH:1].[ClH:1].[ClH:1].[NH2:32][C@H:28]1[CH2:27][C:26]2[CH:40]=[C:22]([CH:23]=[CH:24][C:25]=2[OH:41])[C:21]2=[CH:42][C:17](=[C:18]([OH:43])[CH:19]=[CH:20]2)[CH2:16][C@@H:15]([C:44]([NH:45][CH2:46][CH2:47][CH2:48][C@H:49]([NH2:75])[CH2:50][C:51]([NH:52][CH2:53][C@@H:54]([NH2:66])[CH2:55][CH2:56][CH2:57][NH2:58])=[O:74])=[O:83])[NH:14][C:13](=[O:84])[C@H:12]([CH2:11][CH2:10][CH2:9][NH2:8])[NH:30][C:29]1=[O:31]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89225972HCID 89225972, compound

Product 1

HCID 66879422HCID 66879422, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.32 ml of a 4N solution of hydrogen chloride in dioxane are added to a solution of 25 mg (0.021 mmol) of the compound from Example 262A in 1 ml of dioxane at 0° C. After 2 h at RT, the reaction solution is concentrated in vacuo and coevaporated with dichloromethane several times. The remaining solid is dried to constant weight under high vacuum.

Workup

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customThe remaining solid is dried to constant weight under high vacuum

Sources & evidence

ORD record
ord-06c1eb68942a4e15830b7e66d07ba556
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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