1-Fluoro-3-nitrobenzene → HCID 67388811, compound

HRID 269818Notes

Reaction equation

HRID 269818 reaction equation
F[C:2]1[CH:3]=[C:4]([N+:8]([O-])=O)[CH:5]=[CH:6][CH:7]=1.[N:11]1([CH2:17][CH2:18][NH2:19])[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.[ClH:20].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:20].[N:11]1([CH2:17][CH2:18][NH:19][C:2]2[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=2)[NH2:8])[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 98231-Fluoro-3-nitrobenzeneHCID 4082852-MorpholinoethylamineHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 67388811HCID 67388811, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

3-Fluoronitrobenzene and 2-morpholin-4-yl ethylamine were added, and the resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 and then treated with 4 M hydrogen chloride/ethyl acetate solution in ethyl acetate to obtain 3-[N-(2-morpholin-4-ylethyl)amino]aniline hydrochloride. F: 222.

Sources & evidence

ORD record
ord-d902be205c7d4ceab867a351c3655f4d
Source dataset
uspto-grants-2008_11
Patent number
US07449456B2

Reaction notes

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