Potassium Carbonate → HCID 23071585, compound

HRID 269827Notes

Reaction equation

HRID 269827 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][CH:3]=1.[O:11]=[C:12]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])(C)C)=[O:20])[CH2:15][CH2:14][NH:13]1.C(=O)([O-])[O-].[K+].[K+].[Cl-].[Ca+2].[Cl-]>ClC1C=CC=CC=1Cl.C(O)C.[Cu].[Zn]>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([N:13]2[C:12](=[O:11])[CH2:18][CH2:17][N:16]([C:19]([O:21][CH2:22][C:25]3[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=3)=[O:20])[CH2:15][CH2:14]2)=[CH:3][CH:4]=1

Participants

9

Reactant 4

HCID 11430Potassium CarbonateHCID 124951-Iodo-4-nitrobenzeneHCID 5284359Calcium ChlorideHCID 226177365-Oxo-(1,4)diazepane-1-carboxylic acid tert-butyl ester

Product 1

HCID 23071585HCID 23071585, compound

Reagents, catalysts & solvents 4

HCID 23978CopperCatalystHCID 23994ZincCatalystHCID 702EthanolSolventHCID 72391,2-DichlorobenzeneSolvent

Procedure

4-Iodonitrobenzene and tert-butyl 5-oxo-[1,4]diazepan-1-carboxylate were allowed to undergo the reaction in 1,2-dichlorobenzene in the presence of copper powder and potassium carbonate, and then the nitro group was reduced in ethanol using zinc powder and calcium chloride to obtain benzyl 4-(4-aminophenyl)-5-oxo-1,4-diazepan-1-carboxylate. ESI: 340.

Sources & evidence

ORD record
ord-003a132da29842ec939ebff1847d41bf
Source dataset
uspto-grants-2008_11
Patent number
US07449456B2

Reaction notes

Loading…