反应详情

To a mixture of 4-bromo-3-chlorophenol (2.5 g), potassium carbonate (2.165 g) and N,N-dimethylformamide (26 mL), benzyl chloride (1.8 mL) was added under cooling with ice. Raising the temperature to the ambient level, the system was stirred for 23 hours. The reaction mixture was poured in saturated saline solution and the product was extracted with ethyl acetate. The organic layer was washed with saturated saline solution, and dried over anhydrous magnesium sulfate. Distilling the solvent off, the remaining crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=10:1) to provide 4-benzyloxy-1-bromo-2-chlorobenzene (3.029 g).

1. additionwas added
2. temperatureunder cooling with ice
3. temperatureRaising the temperature to the ambient level
4. additionThe reaction mixture was poured in saturated saline solution
5. extractionthe product was extracted with ethyl acetate
6. washThe organic layer was washed with saturated saline solution
7. dry with materialdried over anhydrous magnesium sulfate
8. distillationDistilling the solvent off, the remaining crude product
9. customwas purified on silica gel column chromatography (eluent, hexane: ethyl acetate=10:1)