Diethylcarbamoyl chloride → HCID 23111441, compound

HRID 269906Notes

Reaction equation

HRID 269906 reaction equation
Cl.Cl.COC1C=CC(N2CCNCC2)=CC=1.C(Cl)(=O)CC(C)C.[CH2:24]([O:31][C:32]1[CH:37]=[CH:36][C:35]([N:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)=[CH:34][C:33]=1[F:44])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[CH2:45]([N:47]([CH2:51][CH3:52])[C:48](Cl)=[O:49])[CH3:46]>>[CH2:45]([N:47]([CH2:51][CH3:52])[C:48]([N:41]1[CH2:42][CH2:43][N:38]([C:35]2[CH:36]=[CH:37][C:32]([O:31][CH2:24][C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[C:33]([F:44])[CH:34]=2)[CH2:39][CH2:40]1)=[O:49])[CH3:46]

Participants

5

Reactant 4

HCID 6916Diethylcarbamoyl chlorideHCID 66054Isovaleryl chlorideHCID 27237001-(4-Methoxyphenyl)-piperazine, dihydrochlorideHCID 231114831-(4-Benzyloxy-3-fluorophenyl)piperazine

Product 1

HCID 23111441HCID 23111441, compound

Procedure

Production Example 3 was repeated except that 1-(4-methoxyphenyl)-piperazine dihydrochloride and isovaleryl chloride were replaced with 1-(4-benzyloxy-3-fluorophenyl)piperazine (286 mg) and diethylcarbamoyl chloride (139 μL), respectively, to provide crude N,N-diethyl-4-(4-benzyloxy-3-fluorophenyl)-1-piperazinecarboxamide (370 mg).

Sources & evidence

ORD record
ord-01b03a2f77a643f98084a469ef708001
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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