Hydrochloric Acid → HCID 11387449, compound

HRID 270003Notes

Reaction equation

HRID 270003 reaction equation
[ClH:1].C(OC(=O)[N:8]([CH2:31][CH2:32][CH2:33][C:34]1[CH:39]=[CH:38][C:37]([N+:40]([O-:42])=[O:41])=[CH:36][CH:35]=1)[CH2:9][CH2:10][NH:11][S:12]([C:15]1[C:16]2[CH:17]=[CH:18][N:19]=[CH:20][C:21]=2[CH:22]=[C:23]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:24]=1)(=[O:14])=[O:13])(C)(C)C>CO.ClCCl>[ClH:1].[ClH:1].[N+:40]([C:37]1[CH:38]=[CH:39][C:34]([CH2:33][CH2:32][CH2:31][NH:8][CH2:9][CH2:10][NH:11][S:12]([C:15]2[C:16]3[CH:17]=[CH:18][N:19]=[CH:20][C:21]=3[CH:22]=[C:23]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:24]=2)(=[O:14])=[O:13])=[CH:35][CH:36]=1)([O-:42])=[O:41]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58812046HCID 58812046, compound

Product 1

HCID 11387449HCID 11387449, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Bubble gaseous HCl through a solution of [3-(4-Nitro-phenyl)-propyl]-[2-(7-phenyl-isoquinoline-5-sulfonylamino)-ethyl]-carbamic acid tert-butyl ester (1.9 g, 2.9 mmol) in methanol/dichloromethane (1:1) with cooling for 15 minutes. Remove the solvent under reduced pressure to afford the title compound as a foam.

Workup

  1. temperaturewith cooling for 15 minutes
  2. customRemove the solvent under reduced pressure

Sources & evidence

ORD record
ord-0a8f02ce0f764b849be622bf1c3420ca
Source dataset
uspto-grants-2008_11
Patent number
US07449477B2

Reaction notes

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