1'-Benzyl-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one → HCID 68959958, compound

HRID 270052Notes

Reaction equation

HRID 270052 reaction equation
C(N1CCC(CO)(CC2C=CC=CC=2F)CC1)C1C=CC=CC=1.[CH2:24]([N:31]1[CH2:36][CH2:35][C:34]2([C:40]3[CH:41]=[CH:42][C:43]([F:45])=[CH:44][C:39]=3[C:38](=O)[O:37]2)[CH2:33][CH2:32]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>C1COCC1>[CH2:24]([N:31]1[CH2:36][CH2:35][C:34]2([C:40]3[CH:41]=[CH:42][C:43]([F:45])=[CH:44][C:39]=3[CH2:38][O:37]2)[CH2:33][CH2:32]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 673778971'-Benzyl-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-oneHCID 68961767[1-Benzyl-4-(2-fluorobenzyl)piperidin-4-yl)methanol

Product 1

HCID 68959958HCID 68959958, compoundYield 77.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This reaction was performed as described for (ii) above using 1′-benzyl-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (200 mg, 0.642 mmol), borane THF complex 1M solution (1.34 mL, 1.34 mmol) and THF (3 mL) to give the sub-titled compound (148 mg).

Sources & evidence

ORD record
ord-5f269ca04b4045c2a6e89ce237e5ede7
Source dataset
uspto-grants-2008_11
Patent number
US07449475B2

Reaction notes

Loading…