Methylamine → HCID 68959972, compound

HRID 270089Notes

Reaction equation

HRID 270089 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[CH:9]=[CH:8][C:3]=1[C:4](OC)=[O:5].[CH3:22][NH2:23]>CO>[OH:1][C:2]1[CH:11]=[C:10]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[CH:9]=[CH:8][C:3]=1[C:4]([NH:23][CH3:22])=[O:5]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 10541338Benzoic acid, 2-hydroxy-4-[(4-methoxyphenyl)methoxy]-, methyl ester

Product 1

HCID 68959972HCID 68959972, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of methyl 2-hydroxy-4-[(4-methoxybenzyl)oxy]benzoate (500 mg, 1.73 mmol) in methanol (15 mL) was slowly added aqueous 40% methylamine (3 mL) at 0° C. After addition was complete the reaction mixture was kept on stirring at room temperature for 2 days. The volatiles were removed in vacuo to give the subtitled compound (500 mg).

Workup

  1. customat 0° C
  2. additionAfter addition
  3. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-d2ac80437a044b00b4b6549ecd25c007
Source dataset
uspto-grants-2008_11
Patent number
US07449475B2

Reaction notes

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