HCID 59833546, compound → HCID 59833561, compound

HRID 270576Notes

Reaction equation

HRID 270576 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([C:9]2[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH:14]=2)[CH:6]=[N:7][CH:8]=1>Cl.O1CCOCC1>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[C:5]([C:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH:14]=2)[CH:6]=[N:7][CH:8]=1

Participants

4

Reactant 1

HCID 59833546HCID 59833546, compound

Product 1

HCID 59833561HCID 59833561, compoundYield 115.3%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 5-(trifluoromethyl)-3′,6′-dihydro-3,4′-bipyridine-1′(2′H)-carboxylate (50.0 mg, 0.152 mmol) was dissolved in a 4 M solution of HCl in 1,4-dioxane (2 mL) to form a light yellow clear (then cloudy) solution. After being stirred at room temperature for 1 h, the reaction mixture was concentrated in vacuo to afford 40.0 mg (87%) of product as a yellow gum. LC-MS calculated for C11H11F3N2: (M+H) 229; found 229.0.

Workup

  1. customto form a light yellow clear (then cloudy) solution
  2. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-30a2741e702641a496af2d295e79101a
Source dataset
uspto-grants-2008_11
Patent number
US07449467B2

Reaction notes

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