反应详情

2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone (0.834 g, 3.3 mmol) was taken in dry DMF (15 mL) and dry potassium carbonate (1.6 g, 11.6 mmol) was added to it and the reaction mixture stirred at room temperature for 1 h under nitrogen. 7-Nitro-1H-indazole (0.5 g, 2.9 mmol) in DMF (2 mL) was then added to the mixture through a syringe. The reaction was then heated at 70° C. for 14 h, cooled and then quenched with water and extracted with ethyl acetate. Drying of the organic layer with Na2SO4 followed by concentration afforded material that was purified on neutral alumina column (pet ether/ethyl acetate). The resulting solid was recrystallized from DCM/pet ether to obtain pure product as a pale yellow solid.

1. temperatureThe reaction was then heated at 70° C. for 14 h
2. temperaturecooled
3. customquenched with water
4. extractionextracted with ethyl acetate
5. dry with materialDrying of the organic layer with Na2SO4
6. concentrationfollowed by concentration
7. customafforded material that
8. customwas purified on neutral alumina column (pet ether/ethyl acetate)
9. customThe resulting solid was recrystallized from DCM/pet ether
10. customto obtain pure product as a pale yellow solid