Hydrochloric Acid → HCID 178428975, compound

HRID 271087Notes

Reaction equation

[F:1][C:2]1[CH:33]=[C:32]([F:34])[CH:31]=[CH:30][C:3]=1[O:4][C:5]1[N:10]=[C:9]2[N:11](COCC[Si](C)(C)C)[N:12]=[C:13]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][C:15]=3[CH3:21])[C:8]2=[CH:7][N:6]=1.Cl>>[F:1][C:2]1[CH:33]=[C:32]([F:34])[CH:31]=[CH:30][C:3]=1[O:4][C:5]1[N:10]=[C:9]2[NH:11][N:12]=[C:13]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][C:15]=3[CH3:21])[C:8]2=[CH:7][N:6]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 1360666024-[6-(2,4-difluoro-phenoxy)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-3-methyl-phenol

Product 1

HCID 178428975HCID 178428975, compound

Procedure

4-[6-(2,4-Difluoro-phenoxy)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-3-methyl-phenol was treated with HCl using the procedure described in step 8 of Example 11 to afford 0.20 g of 4-[6-(2,4-difluoro-phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-3-methyl-phenol. Mass Spec. M+H=355.

Sources & evidence

ORD record: ord-78aa2d7ec8c54b1ca0633e59dda921ef
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07452880B2

Reaction notes

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