Benzylamine → HCID 58758771, compound

HRID 271265Notes

Reaction equation

HRID 271265 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]([OH:14])=O)=[C:4]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[N:3]=1.C(C1NC=CN=1)(C1NC=CN=1)=O.[CH2:32]([NH2:39])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>CN(C=O)C.O>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]([NH:39][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:14])=[C:4]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[N:3]=1

Participants

6

Reactant 3

HCID 7504BenzylamineHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 59834998HCID 59834998, compound

Product 1

HCID 58758771HCID 58758771, compoundYield 66%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A suspension of 2-amino-6-(2-furyl)-9H-purine-9-acetic acid (129 mg, 0.5 mmol) in DMF (2 mL) was treated with carbonyl diimidazole (81 mg, 0.5 mmol), stirred at room temperature for 1 h, treated with benzylamine (55 μL, 0.5 mmol), stirred at room temperature for 2 h, diluted with water, filtered and dried to give the title compound (115 mg, 66%) as a white solid.

Workup

  1. stirringstirred at room temperature for 2 h
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-b6a7f8434d204cc7b5fb1e584bed9c16
Source dataset
uspto-grants-2008_11
Patent number
US07452894B2

Reaction notes

Loading…