反应详情

A solution of 6-(2-furyl)-9-(3-nitrobenzyl)-9H-purine-2-amine (400 mg, 1.12 mmol) in EtOH (10 mL) at 50° C. was treated with a solution of SnCl2.2H2O (808 mg, 3.58 mmol) in conc.HCl (1.8 mL, 21.42 mmol), stirred for 1.5 h, cooled, basified to pH 10 (1-M NaOH) and the resulting solid was filtered, suspended in methanol, treated with HCl in dioxane (4-M, 2 mL), diluted with diethyl ether and filtered to give the title compound (90 mg, 22%) as a yellow solid.

1. temperaturecooled
2. filtrationthe resulting solid was filtered
3. additiontreated with HCl in dioxane (4-M, 2 mL)
4. additiondiluted with diethyl ether
5. filtrationfiltered