Dabco → HCID 58758763, compound

HRID 271275Notes

Reaction equation

HRID 271275 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)=[C:4]([C:19]2[O:20][CH:21]=[CH:22][CH:23]=2)[N:3]=1.C1N2CC[N:26](CC2)[CH2:25]1>C(#N)C>[O:20]1[CH:21]=[CH:22][CH:23]=[C:19]1[C:4]1[N:3]=[C:2]([C:25]#[N:26])[N:10]=[C:9]2[C:5]=1[N:6]=[CH:7][N:8]2[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 9237DabcoHCID 5270752HCID 5270752, compound

Product 1

HCID 58758763HCID 58758763, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 2-chloro-6-(2-furyl)-9-(4-methylbenzyl)-9H-purine (0.10 g, 0.31 mmol) and Et4NCN (0.10 g, 0.62 mmol) in acetonitrile (10 mL) was treated with DABCO (0.07 g, 0.62 mmol), stirred for 48 h, concentrated in vacuo, dissolved in chloroform (50 mL), washed with water (2×30 mL), dried (MgSO4) and concentrated in vacuo to give the title compound (56 mg, 57%) as a pale green solid.

Workup

  1. concentrationconcentrated in vacuo
  2. dissolutiondissolved in chloroform (50 mL)
  3. washwashed with water (2×30 mL)
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-276d443d4a5f4d5b9b45a8de69a32e60
Source dataset
uspto-grants-2008_11
Patent number
US07452894B2

Reaction notes

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