反应详情

To a stirred solution of 7-(4-chlorophenyl)-5-(methylthio)-8-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one (100 mg, 0.27 mmol) in DMF (2 mL) at room temperature under argon was added 5-(chloromethyl)-2-(trifluoromethyl)pyridine (64.4 mg, 0.33 mmol), followed by K2CO3 (74.5 mg, 0.54 mmol). The resulting mixture was stirred at room temperature for 5 h. The crude product was purified by silica gel column chromatography eluted with ethyl acetate—hexanes, then lyophilized from 1,4-dioxane, to obtain the title compound (107.5 mg) as an off-white lyophilate. HPLC/MS: retention time=4.24 min, [M+H]30 =528.

1. customThe crude product was purified by silica gel column chromatography
2. washeluted with ethyl acetate—hexanes