Ammonium Hydroxide → HCID 58772836, compound

HRID 271445Notes

Reaction equation

HRID 271445 reaction equation
Cl[C:2]1[N:7]2[C:8](=[O:11])[NH:9][N:10]=[C:6]2[C:5]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[C:4]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[N:3]=1.[OH-].[NH4+:27]>C1COCC1>[NH2:27][C:2]1[N:7]2[C:8](=[O:11])[NH:9][N:10]=[C:6]2[C:5]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[C:4]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[N:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 587728405-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one

Product 1

HCID 58772836HCID 58772836, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirring solution of 5-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one (120 mg, 0.31 mmol) in 3 mL THF, was added ammonium hydroxide (28% in water, 0.12 mL, 1.8 mmol). The reaction mixture was stirred at room temperature for 3 h and then concentrated under reduced pressure. The resulting crude title compound was used in the next step without further purification. HPLC/MS: retention time=3.60 min, [M+H]30 =372.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe resulting crude title compound was used in the next step without further purification

Sources & evidence

ORD record
ord-0015eea386804732b895b38851934da1
Source dataset
uspto-grants-2008_11
Patent number
US07452892B2

Reaction notes

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