Anthranilamide → HCID 819654, compound

HRID 271540Notes

Reaction equation

HRID 271540 reaction equation
[C:1]([NH2:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[CH:11]1([C:17](Cl)=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C(N(CC)CC)C>ClCCl>[CH:11]1([C:17]([NH:4][C:3]2[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=2[C:1]([NH2:10])=[O:9])=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 6942AnthranilamideHCID 8471TriethylamineHCID 75938Cyclohexanecarbonyl chloride

Product 1

HCID 819654HCID 819654, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Anthranilamide was treated with cyclohexanecarbonyl chloride and triethylamine in dichloromethane, followed by washing (10% citric acid; water; sat. sodium bicarbonate; and sat. sodium chloride) and evaporated to give a nearly quantitative yield of 2-(cyclohexylcarbonylamino)benzamide as a white solid, which was used immediately in the next step.

Workup

  1. washby washing (10% citric acid; water; sat. sodium bicarbonate; and sat. sodium chloride)
  2. customevaporated

Sources & evidence

ORD record
ord-8948d6da0dd74c0b868e830c3dee5af4
Source dataset
uspto-grants-2008_11
Patent number
US07452912B2

Reaction notes

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