反应详情

6-Bromomethyl-7-(2,2-dimethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile (0.33 mmol) and 1H-tetrazole (0.65 mmol) are dissolved in DMF (3 ml). To the solution, K2CO3 (0.98 mmol) is added and the mixture is stirred at room temperature under nitrogen atmosphere for 23 h. The reaction mixture is diluted with water and extracted with AcOEt. The organic layer is washed with brine, dried over sodium sulfate, and concentrated. The crude product is purified by silica gel column chromatography to give A in 45% yield and B in 48% yield in the order of elution.

1. extractionextracted with AcOEt
2. washThe organic layer is washed with brine
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated
5. customThe crude product is purified by silica gel column chromatography
6. customto give A in 45% yield and B in 48% yield
7. washin the order of elution