反应详情

A solution of 3.0 g (11.8 mmol) 4-bromo-1-methoxy-2-trifluoromethyl-benzene in 20 mL 1 M HBr in glacial acetic acid is stirred for 60 h at 90° C. The reaction solution is diluted with 300 mL water, adjusted to pH 7 with K2CO3. The aqueous phase is extracted with EtOAc, the combined organic extracts are with washed 40 mL quarter-saturated NaHCO3 solution and dried over MgSO4. The solvent is eliminated i.vac. and the product is further reacted without any more purification.

1. extractionThe aqueous phase is extracted with EtOAc
2. washwith washed 40 mL quarter-saturated NaHCO3 solution
3. dry with materialdried over MgSO4
4. customand the product is further reacted without any more purification