Hydrochloric Acid → Hydrochloric Acid

HRID 271890Notes

Reaction equation

HRID 271890 reaction equation
[N:1]([C:4]1[C:5]([NH:11]C(=O)C(C)(C)C)=[N:6][CH:7]=[C:8]([F:10])[CH:9]=1)=[N+:2]=[N-:3].[ClH:18]>>[N:1]([C:4]1[C:5]([NH2:11])=[N:6][CH:7]=[C:8]([F:10])[CH:9]=1)=[N+:2]=[N-:3].[ClH:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22293288N-(3-Azido-5-fluoropyridin-2-yl)-2,2-dimethylpropanamide

Product 2

HCID 313Hydrochloric AcidHCID 222932423-Azido-5-fluoropyridin-2-amine

Procedure

N-(3-Azido-5-fluoropyridin-2-yl)-2,2-dimethylpropanamide (275 mg, 1.16 mmol) in 3 N HCl (5 mL) was heated to 100° C. After 2 h, the volatiles were removed in vacuo, to give the title compound as its HCl salt (180 mg). MS 154.2 (M+1).

Workup

  1. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-321efd9e941f4a5a9155c968db9dec32
Source dataset
uspto-grants-2008_11
Patent number
US07452903B2

Reaction notes

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