Hydrochloric Acid → HCID 131727194, compound

HRID 272287Notes

Reaction equation

HRID 272287 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([S:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][CH:25]([NH:36]C(OC(C)(C)C)=O)[CH:26]=[CH:27][P:28](=[O:35])([O:32][CH2:33][CH3:34])[O:29][CH2:30][CH3:31])=[C:18]([Cl:44])[CH:17]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>CO>[ClH:44].[NH2:36][CH:25]([CH2:24][CH2:23][CH2:22][C:19]1[CH:20]=[CH:21][C:16]([S:15][C:11]2[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH:10]=2)=[CH:17][C:18]=1[Cl:44])[CH:26]=[CH:27][P:28](=[O:35])([O:32][CH2:33][CH3:34])[O:29][CH2:30][CH3:31]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 74016630HCID 74016630, compound

Product 1

HCID 131727194HCID 131727194, compoundYield 184.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Example 232 (300 mg) was dissolved in methanol (10 mL) containing 10% hydrochloric acid in an ice bath. The mixture was stirred for 6 hours until room temperature and the solvent was concentrated. This gave the desired product as a colorless oil (250 mg).

Workup

  1. concentrationthe solvent was concentrated

Sources & evidence

ORD record
ord-a571060c2e3647e08da566c4eecbd8ef
Source dataset
uspto-grants-2008_11
Patent number
US07456157B2

Reaction notes

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