反应详情

An ice-cooled solution of 2.28 g (10.0 mmol) of 5-Bromo-2,4-dichloropyrimidine and 3.4 ml (24.0 mmol) of triethylamine in 10 ml of acetonitrile is mixed with 1.82 g (12.1 mmol) of trans-2-aminocyclohexanol hydrochloride. After 16 hours at room temperature the batch is filtrated and the filtrate is concentrated by evaporation. The remaining residue is purified by chromatography (hexane/ethyl acetate: 1:1). 1.61 g (5.3 mmol, corresponding to 53% of theory) of the product is obtained.

1. filtrationAfter 16 hours at room temperature the batch is filtrated
2. concentrationthe filtrate is concentrated by evaporation
3. customThe remaining residue is purified by chromatography (hexane/ethyl acetate: 1:1)
4. custom1.61 g (5.3 mmol, corresponding to 53% of theory) of the product is obtained