1,2-Ethanediamine, N1,N1,N2-trimethyl- → HCID 69219198, compound

HRID 272720Notes

Reaction equation

HRID 272720 reaction equation
Br[CH2:2][C:3]1[CH:19]=[CH:18][C:6]2[NH:7][C:8](=[O:17])[C:9]3[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:10]=3[NH:11][C:5]=2[CH:4]=1.[CH3:20][N:21]([CH3:26])[CH2:22][CH2:23][NH:24][CH3:25]>C(OCC)(=O)C>[Cl:16][C:13]1[CH:14]=[CH:15][C:9]2[C:8](=[O:17])[NH:7][C:6]3[CH:18]=[CH:19][C:3]([CH2:2][N:24]([CH2:23][CH2:22][N:21]([CH3:26])[CH3:20])[CH3:25])=[CH:4][C:5]=3[NH:11][C:10]=2[CH:12]=1

Participants

4

Reactant 2

HCID 673381,2-Ethanediamine, N1,N1,N2-trimethyl-HCID 69219731HCID 69219731, compound

Product 1

HCID 69219198HCID 69219198, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of Example 512A (50 mg, 0.15 mmol) and N,N,N′-trimethylethylenediamine (300 μL, 2.3 mmol) was heated at 50° C. overnight, cooled to room temperature, diluted with ethyl acetate, washed with water and brine, dried (MgSO4), filtered, and concentrated under vacuum to provide 31.5 mg (59%) of the desired product.

Workup

  1. washwashed with water and brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-56c81fe9ede740c78f548855b7a4be90
Source dataset
uspto-grants-2008_11
Patent number
US07456169B2

Reaction notes

Loading…