Azepane → HCID 69114582, compound

HRID 272789Notes

Reaction equation

HRID 272789 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([Cl:12])(=[O:11])=[O:10])#[N:2].[NH:13]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.Cl.NCC1C=CC=CC=1S(N(C(C)(C)C)C)(=O)=O>>[ClH:12].[N:13]1([S:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[CH2:1][NH2:2])(=[O:11])=[O:10])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 8119AzepaneHCID 5223472-Cyanobenzenesulfonyl ChlorideHCID 69273622HCID 69273622, compound

Product 1

HCID 69114582HCID 69114582, compound

Procedure

A (125 mg) was prepared in two steps from 2-cyanobenzene-1-sulfonyl chloride (100 mg) and azepane in 82% overall yield following procedures analogous to those used in the preparation of 2-(aminomethyl)-N-tert-butyl-N-methylbenzenesulfonamide hydrochloride salt. LC-MS: 269.25 (M+H)+.

Workup

  1. customoverall yield

Sources & evidence

ORD record
ord-5cb3f5d846fd4fe6b1d8c5f2e3c85929
Source dataset
uspto-grants-2008_11
Patent number
US07456195B2

Reaction notes

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