1-Bromo-3-chloropropane → HCID 61287344, compound

HRID 272911Notes

Reaction equation

HRID 272911 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][OH:5].[OH-].[Na+].Br[CH2:9][CH2:10][CH2:11][Cl:12]>CC(C)=O>[Cl:12][CH2:11][CH2:10][CH2:9][N:2]([CH3:1])[CH2:3][CH2:4][OH:5]

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 80162-(Methylamino)ethanolHCID 14798Sodium Hydroxide

Product 1

HCID 61287344HCID 61287344, compoundYield 56.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-(Methylamino)-ethanol (1.0 g, 13.3 mmol), acetone (20 ml, 20 vol), 5M NaOH solution (3.19 ml, 1.2 eq.) and 1-bromo-3-chloropropane (6.28 g, 39.9 mmol, 3 eq.) were reacted together according to general procedure A to give the title compound (1.14 g, 55%) as a colourless oil.

Sources & evidence

ORD record
ord-3393ce48cbe146ebba018bda53b659c2
Source dataset
uspto-grants-2008_11
Patent number
US07456164B2

Reaction notes

Loading…