反应详情

温度

90 °C

7-Methoxyimidazo[1,2-a]pyridine (621 mg, 4.2 mmol) was mixed with POCl3 (16.8 mmol) in dimethylformamide (4 mL). The reaction mixture was heated at 90° C. for 24 h and then cooled to room temperature. After the solvent was removed in vacuo, an oil was obtained. The oil was purified on a silica gel column eluting with EtOAc/Hexane (1:1) to afford 7-methoxyimidazo[1,2-a]pyridine-3-carbaldehyde (508 mg, 69%).

1. temperaturecooled to room temperature
2. customAfter the solvent was removed in vacuo
3. customan oil was obtained
4. customThe oil was purified on a silica gel column
5. washeluting with EtOAc/Hexane (1:1)