反应详情

A mixture of A mixture of 2-(5-methoxypyridin-2-yl)-1-(3,4,5-trimethoxyphenyl)ethanone (0.200 g, 0.631 mmol), 1-bromo-2-butanone (0.190 g, 1.3 mmol), and NaHCO3 (0.212 g, 2.6 mmol) in acetone (5 mL) was heated under reflux for 20 h. The precipitate was removed by filtration. The filtrate was concentrated to give a residue, which was purified on a silica gel column eluting with CH2Cl2 to afford compound 6 (0.213 g, 92%).

1. temperaturewas heated
2. temperatureunder reflux for 20 h
3. customThe precipitate was removed by filtration
4. concentrationThe filtrate was concentrated
5. customto give a residue, which
6. customwas purified on a silica gel column
7. washeluting with CH2Cl2